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4-Fluoroamphetamine (4-FA; 4-FMP; PAL-303; “Flux”), also known as para-fluoroamphetamine (PFA) is a psychoactive research chemical of the phenethylamine and substituted amphetamine chemical classes. It produces stimulant and entactogenic effects
4-FA is named 4-Fluoroamphetamine,aslo known as 4FA 4-FMP; PAL-303; “Flux”;PFA).It belongs to the phenethylamine and substituted amphetamine chemical classes.Acts as a recreational drug.Buy 4-FA online
4-FA does not cause long-lasting depletion of brain serotonin, unlike its analogs 4-CA and 4-BA. This is thought to “reflect the inability of the fluoro-compound to be metabolized in the same way as the other haloamphetamines.
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The subjective effects of 4-FA include euphoria which some find similar to the effects of MDMA, increased energy (stimulation), mood elevation, feelings of warmth and empathy, excessive talking, bruxism, and suppressed appetite (anorexic). The general course of effects involves primarily empathogenic effects for the first few hours, which fades out as increased stimulation develops over the next several hours.
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It’s generally described as a cross between amphetamine and MDMA. The effects are cleaner and more entactogenic than amphetamine, but definitely not as entactogenic as MDMA.
The wakefulness is equivalent to or greater than MDMA, as is the case with some of the pro-social effects. Users don’t report the stimulation to be very forced or uncomfortable in most cases.
As was already mentioned, the effects are dose-dependent. It’ll be primarily like amphetamine under 100 mg and a bit more MDMA-like over 100 mg.
Users tend to report a calm mindset with the drug and the chance of anxiety or agitation appears lower than with amphetamine. It’s often very pro-social with common or strong doses. An MDMA-like floatiness may be present.
The effects often have a wave-like nature, meaning there can be short periods where it feels like you’re much closer to sober. 4-FA has a smooth onset period and typically doesn’t produce a negative comedown or strong negative day-after effects.
If you’re taking a more recreational amount, the main effects will last 4-5 hours and be followed by more amphetamine-like stimulation for a few more hours.
It’s not going to be particularly useful as a productive stimulant when over 100 mg is used. Around 50 to 75 mg is reportedly useful as a productivity aid, similarly to common amounts of amphetamine. Also, it may be productive once the core entactogenic-like effects have worn off with higher doses.
A 2015 survey of 249 people in the Netherlands gives some idea of the typical effects and how 4-FA is used. Most people reported taking it in festivals, dance parties, and clubs. They primarily obtained it through friends or online shops.
77.1% used the drug because of its specific effects, not because of its legal status. Most participants first reported taking it around 2013.
Oral was the most common route of administration (92.8%). 100 – 150 mg was the most common dose range, though close to 20% used over 150 mg.
Participants said it lasted either 4 to 6 hours or 6 to 8 hours.
The actual effect scores were between those for MDMA and amphetamine.
Compared to amphetamine
- Less irritability
- Greater talkative and pro-social effects
- Lower “craving” score
- Similar for alertness and stimulation
- Greater euphoria and “connectedness to others”
- Greater “changes in sensory perception.”
Compared to MDMA
- Lower intensity, confusion, and dizziness
- Lower “craving”
- Lower euphoria and “connectedness to others”
- Lower “changes in sensory perception.”
Chemistry & Pharmacology
4-FA is a substituted amphetamine. It has a fluorine added to the core amphetamine structure.
The synthesis reportedly involves 4-fluoro-P2P (aka 4-fluoro-BMK).
The drug functions as a monoamine releaser and reuptake inhibitor. Serotonin, dopamine, and norepinephrine are all elevated.
Its pharmacology (like the effects) is between that of MDMA and amphetamine. 4-FA has lower dopamine:serotonin and DAT:SERT ratios than amphetamine, but MDMA still has a greater effect on serotonin.
- DAT (IC50)
- 4 uM
- SERT (IC50)
- 20 uM
- NET (IC50)
- 0.4 uM
- Dopamine release (ED50)
- 200 nM
- Serotonin release (ED50)
- 1000+ nM
- Norepinephrine release (ED50)
- 50 nM
4-FA is 2x more potent than 4-chloroamphetamine as a dopamine reuptake inhibitor and 13x less potent as a serotonin reuptake inhibitor.
There appears to be some minor MAOI activity, though the potency is lower than 4-chloroamphetamine and 4-bromoamphetamine.
Corticosterone release is stimulated. 4-chloroamphetamine is also more potent in this regard. The release might not be connected to 4-FA’s serotonergic activity.
United States (as of June 2017)
State schedules: Arizona, Florida, Louisiana, and Virginia.
Controlled (list may not be complete)
Brazil, Canada (due to amphetamine analog status), China, France, Germany, Hungary, Israel, Italy, the Netherlands, Poland, Slovakia, Serbia, and the UK.
We don’t have enough information about 4-FA to tell how safe it’ll be in the long-term, especially with heavy chronic use. For this reason, it should be used infrequently at common doses and without combinations.
This isn’t clear for humans, but we do have some animal data.
- 46 mg/kg IP (potential human equivalent of 3.7 mg/kg)
- Mouse (male)
- 150 mg/kg oral (potential human equivalent of 12.2 mg/kg)
- Mouse (female)
- 25 mg/kg oral (potential human equivalent of 2.0 mg/kg)
Evidence suggests 2.0 mg/kg and 3.7 mg/kg aren’t accurate. It could potentially be somewhere between 3.7 and 12.2 mg/kg.
Animal studies suggest it has a relatively low potential for neurotoxicity. Even when serotonin depletion is seen, it’s short-lasting and isn’t indicative of damage.
One report in rats showed no signs of neurotoxicity 16 hours after an injection. Another report showed no decline in serotonin or 5-HIAA concentrations at 10 ug/kg. There was a temporary decline at 100 ug/kg.
The research suggests neurotoxicity isn’t as much of a concern as it would be for the bromo and chloro substitutions.
It’s wise to avoid using the drug daily or near daily when taking light or low-common doses. When taking over 100 mg, it’s best to at least wait a month between uses, preferably a few months out of an abundance of caution.